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To investigate the impact of shifting from cystine-driven to GSH-driven cysteine supply in cancer cells in an unbiased manner, we performed a multifunctional approach to pharmacological screening (MAPS) with a library of 240 metabolic inhibitors (Fig
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Enzymes that catalyze antioxidant reactions: Reduced glutathione (G-SH), a tripeptide-thiol (γ-glutamylcysteinylglycine) present in most cells, can chemically detoxify H 2 O 2 (Figure 13.5B)
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