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This preventative role of GSTs in tumorigenesis is due to the mitigation of DNA damage caused by xenobiotics, carcinogens, and oxidation that could otherwise cause oncogenic mutations if not for the detoxification and peroxidase activities of this family of enzymes

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doi: 10.2147/CMAR.S159660, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 501