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The framing: NNMT inhibition conserves nicotinamide for NAD+ production while also restoring SAM-dependent methylation — a dual metabolic effect that NR or NMN supplementation alone would not reproduce, since those compounds add to the NAD+ pool without addressing the methylation drain

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Even those who occasionally eat animal products may not consume enough to meet daily needs, particularly if they rely heavily on processed or plant-based convenience foods