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Considering that the concentrations of free GSH in the mitochondrial matrix are similar to those in the cytoplasm, that synthesis appears to occur exclusively in the cytoplasm, and that the GSH molecule is a zwitterion, containing both positive and negative charges (2 negative charges on carboxylate groups, a thiol group that is partially deprotonated at physiological pH, and one positive charge on an amine group), it seemed likely to us that the mitochondrial pool of GSH is derived from transport from the cytoplasm via the function of specific carrier proteins (see [82–84] for reviews)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 27.Lee WJ, Kim M, Park HS, Kim HS, Jeon MJ, Oh KS, et al