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Glutamic Acid Decarboxylases Biosynthesis of GABA from L-glutamate is a one-step reaction catalyzed by paralogous pyridoxal 5′-phosphate (PLP)-dependent glutamic acid decarboxylases GAD65 (encoded by GAD2 ), GAD67 (encoded by GAD1 ) or the isoforms of the latter, such as enzymatically active GAD44, corresponding to the C-terminus of the enzyme [46]
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