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In the first step, GSH forms an adduct with methylglyoxal (synonyms, 2-oxopropanal and pyruvaldehyde), a potentially toxic byproduct of glycolysis (Chakraborty et al., 2014, Allaman et al., 2015), yielding the glutathione S -conjugate S -d-lactoylglutathione in a reaction catalyzed by glyoxalase I
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A peer-reviewed review published in the International Journal of Molecular Sciences (Pickart & Margolina, 2018) discusses GHK-Cu's investigated interactions with biological processes involving collagen, elastin, fibroblasts, and tissue repair, drawing on decades of laboratory and clinical research into the ingredient
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