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Though allergies to cobalt are rarely dangerous, taking any form of B12 supplement, whether by injection, tablet, or topically applied gel, may result in an uncomfortable, itchy rash

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Gallbladder problems – right upper abdominal pain, particularly after eating fatty foods Severe allergic reactions – rash, swelling of face or throat, difficulty breathing Diabetic retinopathy complications – sudden vision changes (in patients with pre-existing retinopathy) Acute kidney injury – particularly in the context of severe dehydration The MHRA advises that patients should be counselled about these risks before starting treatment