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(2022) indicated a significant increase of basic sperm parameters including sperm concentration, total motility, progressive motility and normal forms following AOX therapy versus placebo or no treatment ( in vitro glycine supplementation has been found to improve the quality of cryopreserved sperms in an animal experiment ( According to data from the Cochrane review, administration of carnitines and combined AOX formulations had positive effect of sperm motility, and supplementation with polyunsaturated fats and zinc resulted in increase of sperm concentration ( Sperm recovery in patients with non-obstructive azoospermia A study investigated the outcome of three-month supplementation with multivitamins, micronutrients and CoQ10 in infertile men with non-obstructive azoospermia (n=24) as compared to no treatment (n=11) ( Sperm DNA fragmentation Folic acid supplementation resulted in lowering the levels of SDF in carriers of MTHFR gene TT polymorphism ( Seminal oxidative stress indices Few studies demonstrated improvement in OS as determined by reduction of levels of malonaldehyde (MDA), a lipid peroxidation byproduct following therapy with Vitamin C, vitamin E, beta-carotene, zinc, selenium, and NAC when used alone or in combination ( Clinical pregnancy rate and live-birth rate Recent years have wetnessed a growing interest in the study of the impact of AOX therapy on clinical pregnancy rate (CPR) and live-birth rate (LBR)

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