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Noteworthy, although apoptosis is considered to be a result of neurodegeneration, alterations in signaling pathways related to apoptosis have been widely described to be implicated in neurodegenerative diseases, such as AD (Obulesu and Lakshmi, 2014), Parkinson’s disease (Lev et al., 2003), and amyotrophic lateral sclerosis (Sathasivam et al., 2001)