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There was no change in the C57BL/6J mouse hepatic mitochondrial [NAD + ]/[NADH] with aging, as shown by measurements of the acetoacetate/beta-hydroxybutyrate (Hagopian et al., 2003), while there was also no change in the C57BL/6J mouse hepatic cytoplasmic [NAD + ]/[NADH] or [NADPH]/[NADP + ] with aging, as shown by measurements of the pyruvate/lactate and malate/pyruvate, respectively (Hagopian et al., 2003, 2009)
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