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Redox-Active Small Molecule ArsR Sensors The remainder of the biochemically characterized ArsR family sensors are not metal ion or metalloid-sensing regulators, but instead use cysteine thiolate chemistry enabled by a precisely tuned p K a , nucleophilicity and topology to specifically sense either RSS or ROS (Figure 10E)
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Moreover, dysbiosis predisposes to alterations of the integrity and permeability of the BBB initiated by the inflammatory response [27]
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