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The groups that received the riboflavin-fortified salt had lower rates of esophageal cancer.[ref] Inflammatory Bowel Disease (IBD): In patients with Crohn’s disease, riboflavin (100mg/day) decreased inflammatory markers significantly in three weeks.[ref] Related article: IBD and Genetic Connections Inflammation: A randomized, placebo-controlled trial of supplemental riboflavin found that it reduced inflammation based on a lower CRP level.[ref] Related article : Inflammation and chronic disease Sleep quality: A 2025 randomized, double-blind, placebo-controlled trial found that supplementing with 100mg of vitamin B1 and 100mg vitamin B2 enhanced sleep quality and reduced stress

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Alternatively, in the presence of cigarette smoke, Nrf2 may stay in the cytoplasm, and in the presence of NAC, it travels to the nucleus and ensue the transcription of antioxidants and inhibits inflammation