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Mechanistically, ALM activates retinoid X receptor-ฮฑ (RXRฮฑ) through stable hydrogen bond formation, thereby upregulating caudal-type homeobox transcription factor 2 (CDX2) and cystic fibrosis transmembrane conductance regulator (CFTR), while concurrently suppressing ฮฒ-catenin/Snail-mediated epithelial-mesenchymal transition (EMT)
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