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The distinct mode of CTR and AMYR engagement by Cagri revealed in the current study, together with the correlated distinctions in functional responses at individual receptors, is likely to be important in the differentiated, high efficacy, of Cagri as a first-in-class obesity drug in both preclinical animal models and in treatment of obese patients in clinical trials 2,3,4
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Meanwhile, in non-selenium containing Gpxs, which represent the majority of non-vertebrate Gpxs, the selenocysteine residue at the active site is replaced by a cysteine residue and the enzyme follows Michaelis Menten saturation kinetics (Toppo et al., 2009)
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